| Date | Location | Result | |
| 3/14/81 | Providence Civic Center/Providence, R.I. | Notre Dame 54, James Madison 45 | Box score |
| 3/12/81 | Providence Civic Center/Providence, R.I. | James Madison 61, Georgetown 55 | Box score |
| 3/7/81 | Hampton Coliseum/Hampton, Va. | James Madison 69, Richmond 60 | Box score |
| 3/6/81 | Hampton Coliseum/Hampton, Va. | James Madison 44, William & Mary 42 | Box score |
| 2/28/81 | Robins Center/Richmond, Va. | James Madison 69, Richmond 63 | Box score |
| 2/25/81 | Godwin Hall/Harrisonburg, Va. | James Madison 85, Towson 53 | Box score |
| 2/21/81 | Godwin Hall/Harrisonburg, Va. | James Madison 77, Shippensburg 68 | Box score |
| 2/18/81 | Scope/Norfolk, Va. | James Madison 73, Old Dominion 65 | Box score |
| 2/12/81 | Godwin Hall/Harrisonburg, Va. | Virginia Commonwealth 58, James Madison 57 | Box score |
| 2/7/81 | Godwin Hall/Harrisonburg, Va. | James Madison 72, William & Mary 60 | Box score |
| 2/4/81 | Towson Center/Towson, Md. | James Madison 73, Towson 58 | Box score |
| 1/31/81 | Godwin Hall/Harrisonburg, Va. | James Madison 77, Charleston Southern 52 | Box score |
| 1/28/81 | Godwin Hall/Harrisonburg, Va. | James Madison 73, Navy 55 | Box score |
| 1/26/81 | Richmond Coliseum/Richmond, Va. | Virginia Commonwealth 50, James Madison 49 | Box score |
| 1/24/81 | Godwin Hall/Harrisonburg, Va. | James Madison 70, George Mason 53 | Box score |
| 1/21/81 | Godwin Hall/Harrisonburg, Va. | Old Dominion 65, James Madison 63 | Box score |
| 1/17/81 | William & Mary Hall/Williamsburg, Va. | William & Mary 44, James Madison 42 | Box score |
| 1/14/81 | Godwin Hall/Harrisonburg, Va. | James Madison 90, Baltimore 59 | Box score |
| 1/10/81 | Godwin Hall/Harrisonburg, Va. | James Madison 92, Richmond 73 | Box score |
| 1/7/81 | Godwin Hall/Harrisonburg, Va. | James Madison 97, North Carolina Wesleyan 57 | Box score |
| 1/3/81 | GMU Fieldhouse/Fairfax, Va. | James Madison 54, George Mason 37 | Box score |
| 12/30/80 | Godwin Hall/Harrisonburg, Va. | Virginia 53, James Madison 52 | Box score |
| 12/20/80 | Cassell Coliseum/Blacksburg, Va. | James Madison 77, Pittsburgh 69 | Box score |
| 12/19/80 | Cassell Coliseum/Blacksburg, Va. | Texas A&M 51, James Madison 47 | Box score |
| 12/13/80 | Godwin Hall/Harrisonburg, Va. | James Madison 70, Rider 52 | Box score |
| 12/10/80 | Baltimore Civic Center/Baltimore, Md. | James Madison 87, Baltimore 62 | Box score |
| 12/6/80 | Godwin Hall/Harrisonburg, Va. | West Virginia Tech 80, James Madison 78 | Box score |
| 12/2/80 | Godwin Hall/Harrisonburg, Va. | James Madison 74, Salisbury State 54 | Box score |
| 11/29/80 | Alumni Hall/Jamaica, N.Y. | James Madison 49, Weber State 47 | Box score |
| 11/28/80 | Alumni Hall/Jamaica, N.Y. | St. John's 67, James Madison 58 | Box score |